Liverpool lacked cohesion as they suffered a defeat on the opening day at White Hart Lane.
Spurs took the lead through full-back Benoit Assou-Ekotto's impressive strike just before half time. Steven Gerrard briefly leveled from the penalty spot after Glen Johnson was brought down after a good run from the right, but Sebastien Bassong headed the home side back in the lead within minutes.
Liverpool were denied a late penalty when sub Andriy Voronin was clearly fouled but in all honesty Spurs deserved the win and questions will already be asked of Rafa Benitez's side.
BBC’s Phil McNulty: Rafael Benitez can have few complaints as Liverpool – heavily tipped to end Manchester United’s run of three successive Premier League titles – delivered a lame display which lacked attacking invention and genuine quality.
Tottenham: Gomes, Corluka, King, Bassong, Assou-Ekotto, Lennon, Huddlestone, Palacios, Modric (O’Hara, 83), Keane (Crouch, 68), Defoe (Pavlyuchenko, 92)
Liverpool: Reina, Johnson, Carragher, Skrtel (Ayala, 75), Insua, Mascherano, Lucas, Kuyt (Voronin, 79), Gerrard, Babel (Benayoun, 67), Torres
Referee: Phil Dowd